Page 114 - Proceeding The 2nd International Seminar of Science and Technology : Accelerating Sustainable Innovation Towards Society 5.0

nd
The 2 International Seminar of Science and Technology
“Accelerating Sustainable innovation towards Society 5.0”
ISST 2022 FST UT 2022
Universitas Terbuka

Figure 4. Lytic and lysogenic mechanism. [38]
Studies about phage as an alternative treatment have been carried
out for a long time. Phage is considered to be the alternative for
bacterial infection treatment because of several reasons such as
phage is a natural predator of bacteria that is specific, do not affected
by the ability of bacterial resistance, has ability to produce enzymes
that lead to biofilm degradation and infect bacteria in it, and can infect
persister cells or dormant bacteria [34][1], [39].
Phages are obligate intracellular parasites which need a host to
replicate. Without bacteria as hosts, phages cannot reproduce or
metabolize. Therefore, phages adapt to effectively infect bacteria [33],
[40]. According to [41], phages have a co-evolutionary mechanism
against bacteria that means when bacteria mutate and have
mechanisms to defend from phages, the phages will also adapt to be
able to infect bacteria. On the other hand, antibiotics doesn’t have the
ability to adapt with bacteria resistance. With this co-evolutionary
ability, the phage certainly has the advantage to infect pathogenic
bacteria.

ISST 2022 – FST Universitas Terbuka, Indonesia 93
International Seminar of Science and Technology “Accelerating Sustainable
Towards Society 5.0