Page 107 - Proceeding The 2nd International Seminar of Science and Technology : Accelerating Sustainable Innovation Towards Society 5.0

The 2 International Seminar of Science and Technology
nd
“Accelerating Sustainable innovation towards Society 5.0”
ISST 2022 FST UT 2022
Universitas Terbuka
Bacteriophages are also known to produce enzymes that can degrade
the extracellular matrix. In addition, bacteriophages can also infect
persister cells, i.e. cells that are in the dormant phase. When the cell
is in a dormant state, the phage will also be in a dormant phase.
However, when the cell is metabolically active again, the phage also
becomes active again [1]. In this scientific paper, we will discuss
bacteriophage as an antibiofilm agent for Escherichia coli.

2 RESULT
2.1 Escherichia Coli
Escherichia coli (Figure. 1) is a gram-negative bacterium in the form
of a bacillus with a length of 1-3 µm and a diameter of 0.5 µm. This
bacterium was first isolated from the feces of small children in 1885 by
a pediatrician named Theodor Escherich. E. coli itself is a microbiome
flora in the digestive system of humans and mammals. E. coli can also
be found in soil and water, which makes this bacterium as a
bioindicator of water quality. Apart from being a microbiome flora,
several strains of E. coli can also act as a pathogen that infects the
digestive system and other body parts [6] [7].

Figure 1. Scanning Electron Micrograph of an E. coli. [8]
Pathogenic E. coli are classified into two categories, intestinal E. coli
(InPEC (Intestinal Pathogenic E. coli)) and extraintestinal E. coli
(ExPEC (Extraintestinal Pathogenic E. coli)). E. coli InPEC consists of

86 ISST 2022 – FST Universitas Terbuka, Indonesia
International Seminar of Science and Technology “Accelerating Sustainable
Towards Society 5.0