Page 105 - Proceeding The 2nd International Seminar of Science and Technology : Accelerating Sustainable Innovation Towards Society 5.0

nd
The 2 International Seminar of Science and Technology
“Accelerating Sustainable innovation towards Society 5.0”
ISST 2022 FST UT 2022
Universitas Terbuka
LITERATURE REVIEW: THE POTENTIAL OF
BACTERIOPHAGES AS ANTIBIOFILM OF
ESCHERICHIA COLI

1,2
2*
Yurani Sakinah , Fawzi R. Zuhairi
1 I-engineer (INDONESIA)
2 Biology Study Program, Faculty of Science and Technology,
Universitas Terbuka (INDONESIA)

*Corresponding author: fawzi.zuhairi@ecampus.ut.ac.id

Abstract
Escherichia coli has the potential as a pathogenic bacterium and
causes various diseases such as diarrhea, urinary tract infections, and
meningitis. Other than that, E. coli also known to have the ability to
form biofilm. Biofilm is an extracellular matrix secreted by bacteria that
has function such as protecting bacteria from environmental stress,
immune cells, and antibiotics. This causes problems for diseases
related to E. coli infection because the structure of E. coli biofilm
makes it difficult for antibiotics to penetrate so that bacteria become
resistant to antibiotics. Therefore, an alternative to antibiotics is
needed, and one of the prospective alternatives is bacteriophage.
Bacteriophages are known to have characteristics as an antibiofilm
since it is not affected by the ability of bacterial resistance, has the
ability to produce enzymes that degrade biofilm in the bacteria and
able to infect persister cells or bacterial cells that are dormant.
Moreover, bacteriophages are also known as natural predators of
bacteria. The purpose of this article is to explore and explain the
potential of bacteriophages as antibiofilm of Escherichia coli bacteria.
Keywords: Escherichia coli, pathogen, antibiofilm.

84 ISST 2022 – FST Universitas Terbuka, Indonesia
International Seminar of Science and Technology “Accelerating Sustainable
Towards Society 5.0