Page 259 - Trends in Science and Technology fo Sustainable Living

220 Fakultas Sains dan Teknologi
Universitas Terbuka (2023)

7. Several bioactive compounds have been investigated in
Clitoria ternatea flowers
Clitoria ternatea flowers have diuretic and laxative effects.
They are commonly used to alleviate stomach cramps and
exhibit anti-helminthic, anti-inflammatory, antipyretic, analgesic,
antidepressant, anxiolytic, sedative, anticonvulsant, antineoplastic,
and hypoglycemic activities. In conventional Ayurvedic
medicine, these flowers have been used for hundreds of years as
memory enhancers, nootropics, anti-stress agents, anxiolytics,
antidepressants, anticonvulsants, and tranquilizers. Active
constituents include resin, tannins, taraxerone, starch, and taraxerol.
The plant contains numerous secondary metabolites, including
kaempferol and clitorin glucosides, taraxerol, and aparajitin lactone.
The seeds contain hexacosanal, stigmasterol, and anthoxanthin.
Flowers of Clitoria ternatea have been showed to have
antioxidant, antibacterial, anticancer, and antidiabetic properties.
Various research, however, have looked into their potential for other
positive functions. Adhikary et al. (2018) discovered in a rat model
that a 100% methanol extract of Clitoria ternatea flowers and its
pure component, quercetin-3-D-glucoside, have anti-rheumatic
potential. The extract was less effective than quercetin-3-D-
glucoside in significantly decreasing myeloperoxidase activity, pro-
inflammatory cytokine and chemokine release, and reactive oxygen
species (ROS)/reactive nitrogen species formation. It also lowered
the expression of tumor necrosis factor receptor 1, toll-like receptor
2, the inducible isoform of nitric oxide synthase, COX-2, and matrix
metalloproteinase-2. Singh et al. (2018) discovered that Clitoria
ternatea floral extract had anti-allergic properties—the 98% ethanol
extract reduced histamine-induced contractions in goat tracheal
chains and isolated guinea pig ileum preparations. The extract
also reduced histamine-induced dyspnea in animal models and
regulated different ovalbumin-induced inflammatory cytokines. The
extract inhibited inflammation in carrageenan- and acetic acid-
induced challenges in rodent models, as well as antitussive efficacy
in sulfur dioxide- and citric acid-induced cough in experimental